Objectives To analyse the perspective of clinical research stakeholders concerning post-trial access to study medication. Methods Questionnaires and informed consents were sent through e-mail to 599 ethics committee (EC) members, 290 clinical investigators (HIV/AIDS and Diabetes) and 53 sponsors in Brazil. Investigators were also asked to submit the questionnaire to their research patients. Two reminders were sent to participants. Results The response rate was 21%, 20% and 45% in EC, investigators and sponsors’ groups, respectively. 54 patients answered the questionnaire through (...) their doctors. The least informative item in the consent form was how to obtain the study medication after trial. If a benefit were demonstrated in the study, 60% of research participants and 35% of EC answered that all patients should continue receiving study medication after trial; 43% of investigators believed the medication should be given to participants, and 40% to subjects who participated and benefited from treatment. For 50% of the sponsors, study medication should be assured to participants who had benefited from treatment. The majority of responders answered that medication should be provided free by sponsors; investigators and sponsors believed the medication should be kept until available in the public health sector; EC members said that the patient should keep the benefit; patients answered that benefits should be assured for life. Conclusions Due to the study limitations, the results cannot be generalised; however, the data can contribute to discussion of this complex topic through analysing the views of stakeholders in clinical research in Brazil. (shrink)

La filosofía nace y hunde sus raíces en ese tempestuoso navegar en el que se desenvuelve la vida de los hombres, tratando siempre de responder a necesidades históricas concretas y de buscar respuestas a los problemas de su propio tiempo. Esta solidaridad de la palabra filosófica con ese continuo variar que constituye la vida humana es lo que explica el hecho de que las concepciones filosóficas sean inevitablemente múltiples y diversas, y que los textos de los filósofos no puedan leerse, (...) si se quieren evitar deformaciones de todo tipo, aislándolos del contexto en el que surgieron. Los esfuerzos de aquellos que pretenden situar al discurso filosófico al margen y fuera de la historia real, presentando a la historia de la filosofía como una generación de conceptos nacidos de unos seres que parecen estar situados fuera del espacio y del tiempo, están condenados al fracaso, pues olvidan el hecho de la historicidad misma de la filosofía que va unida a una cultura y a una época determinadas. El presente volumen pretende mostrar el nexo constante que existe entre la historia de la filosofía y la vida de los hombres a través del análisis de cómo pensaron y qué significado y valor dieron a sus propios pensamientos algunos de los más ilustres filósofos que vivieron en tiempos históricos muy diversos. El estudio de los mismos, llevado a cabo por distintos especialistas, nos permitirá contemplar la pluralidad de distintos modos de filosofar y de las filosofías resultantes. (shrink)

The main purpose of the paper is to investigate the relevance and significance of the concept of common good in contemporary society. First, I make a brief historical remark about the philosophical concept of common good. I will argue that the concept is rooted in the ancient Greek philosophical understanding of society, namely as polis, whereby human being is thought to have an end that is not merely individual but also collective. I then discuss how societies have significantly changed over (...) the years and how the current global order resembles the situation during the time of Alexander the Great, whose vision it was to establish a cosmopolis, literally a global city. In the end, I consider whether the notion of common good in itself has lost its relevance in the face of the manifold social changes. I bring my discussion to a close with a note on the universality and naturality of the common good of humankind. (shrink)

Pleasure has always been an important issue in morality. And although ethical systems tend to focus the discussion on human action, this agreeable sentiment has remained a recurrent question in moral philosophy. In this paper, I go back to Aristotle’s treatment of pleasure in his writings, particularly in the Nicomachean Ethics. I will argue that the distinction he draws between bodily pleasures and those of the mind represents an important point not only in understanding eudaimonia but also in situating the (...) very nature of ethical debates today. I will try to show how Aristotle’s distinction among pleasure matches up with his differentiation between energeia and kinésis as well as with the distinction between praxis and poiésis, and how these differentiations have enabled Aristotle toevade the pitfall of hedonism. (shrink)

A la question des athéismes modernes , l'A. répond par la théologie biblique qui se dégage d'Exode 3. Il s'agit du passage où Moïse dialogue avec Dieu qui a pris la forme d'un buisson ardent. Ce qui intéresse plus particulièrement l'A., c'est la révélation de son nom que Dieu fait à Moïse : YHWH, je suis celui qui est ou encore je suis qui je suis. L'A. fait une analyse narrative de la péricope. Celle-ci contient trois noms divins dont l'A. (...) explore les significations et les implications. (shrink)

This text explores how human beings construe experience: experience as a resource, as a potential for understanding, representing and acting on reality.

Recognized in his day as a man of letters equaling Rousseau and Voltaire in France and rivaling Samuel Johnson, David Hume passed from favor in the Victorian age--his work, it seemed, did not pursue Truth but rather indulged in popularization. Although Hume is once more considered as one of the greatest British philosophers, scholars now tend to focus on his thought rather than his writing. To round out our understanding of Hume, M. A. Box in this book charts the interrelated (...) development of Hume's literary ambitions, theories of style, and compositional practice from his Treatise in 1739 through the Enquiries. In so doing, Box makes the case for Hume's career-long concern with the presentational modes of reaching an audience for his philosophical writings. Hume reacted to the popular failure of his masterpiece, A Treatise of Human Nature, Box suggests, by self-consciously exploring strategies in his subsequent works for agreeably bringing his readership to participate in the act of philosophizing. Combining a sensitive grasp of the ways Restoration period and eighteenth-century writers conceived the relations between rhetoric and philosophy with sound readings of particular texts, Box shows how Hume's literary concerns went beyond matters of style to involve persona, structure, and doctrine. While this book helps explain long-standing ambiguities surrounding Hume, especially by pointing out the tension between his created persona and his own voice, it also serves as an excellent introduction to his philosophy. (shrink)

Metabolism is a criterion of life. Three senses are distinguished. The weakest allows strong A-Life: virtual creatures having physical existence in computer electronics, but not bodies, are classes as 'alive'. The second excludes strong A-Life but allows that some non-biochemical A-Life robots could be classed as alive. The third, which stresses the body's self-production by energy budgeting and self-equilibrating energy exchanges of some (necessary) complexity, excludes both strong A-Life and living non-biochemical robots.

The study presents the broad outlines for a relationalist interpretation of the Indian epistemological doctrine svataḥ prāmāṇya. Due to the inadequacy of the main western interpretations thereof, the paper’s approach can be considered an inference to the best explanation. Its main part is devoted to the typologization of various epistemological doctrines based on the svataḥ prāmāṇya principle in terms of strong and weak disjunctivism. Three paradigm cases of strong disjunctivism and a special variety of weak disjunctivism have thus been identified (...) in Indian epistemology, which allowed to draw a conclusion that strong disjunctivism constituted one of its general paradigms. (shrink)

M A B Degenhardt; Sartre, Imagination and Education1, Journal of Philosophy of Education, Volume 9, Issue 1, 30 May 2006, Pages 72–92, https://doi.org/10.1111/j.

Is there an effect of depressed mood on the interpretation of ambiguity? Are depressed individuals biased to interpret ambiguous information in a negative manner? We used a cross-modal semantic priming task to look for evidence of a negative interpretative bias. Participants listened to ambiguous prime sentences (e.g., Joan was stunned by her final exam mark) and made lexical decisions to target words presented immediately after the sentence offset or after a delay of 1000 ms or 2000 ms. For the semantically (...) related targets, the target was negatively related (distress), positively related (success), or neutrally related (grades) to the ambiguous prime. The experiment was conducted with and without a negative mood induction. The expectation was that depressed participants would be more likely to consider the negative interpretations of the ambiguous primes and would therefore experience larger priming effects for negatively related targets. Although there were large priming effects for all semantically related targets, there was no evidence of a negative interpretative bias. (shrink)

This chapter contains sections titled: Philosophies and Philosophers Peters' Authenticity Why Value Authenicity? An Apparent Paradox: Peters' Expressed Disdain for Authenticity Conclusion References.

Many educators persist in opposing art to intellect. This is incompatible with modern understandings of the interdependence of cognition and feeling. It also causes neglect of the value of art as one medium for presenting and exploring ideas. Historical examples add weight to the point by showing the richness of thought that has often informed visual art. The educational waste and cultural damage consequent on neglecting this aspect of art is indicated and remedial approaches are suggested.

R. K. Elliott once commended R. S. Peters' work in philosophy of education for being an authentic expression of the self. Many philosophers, probably including Peters, might see this more as a weakness. In an attempt to resolve this difference various kinds of continuity between philosopher and philosophy are explored. These point to an ideal of a two-way, and ultimately ‘organic’, relationship whereby the philosophy expresses the self and the self is formed by the philosophy. Ways of teaching to favour (...) the development of such authenticity in novice philosophers are discussed. (shrink)